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CAMBRIDGE, MA – October 10, 2024 – XtalPi, a global leader in AI drug discovery, announced today a license agreement between Ailux Biologics, a division of XtalPi Inc., and Janssen Biotech, Inc.,(Janssen), a Johnson & Johnson company, on one of its proprietary biologics AI platforms.
Under the agreement, Ailux Biologics grants Janssen and its affiliates a non-exclusive license to leverage its XtalFold platform for the discovery and engineering of biologics. XtalFold is a proprietary AI-based software suite that provides rapid and accurate structural insights to accelerate biologics innovation across multiple phases. The agreement was facilitated by Johnson & Johnson Innovation.
XtalFold utilizes sequence information alone to model the interaction between biomolecules, which forms the foundation of biotherapeutics like monoclonal antibodies. In rigorous benchmark studies, XtalFold achieved state-of-the-art performance in terms of overall success rate and the quality of hard-to-model regions like the antibody-antigen interface. Since its launch one year ago, XtalFold has been fully validated in more than 30 partner and internal programs, delivering highly impactful results in a variety of use cases, including antigen design, epitope identification, affinity maturation, pH-sensitivity engineering, and bispecifics design.
Yi (Alex) Li, VP of XtalPi and Head of Ailux Biologics, said: “Biologics are intricate machines that operate in three-dimensional space. XtalFold enables the visualization and design of biologics in 3D space in real time, which could take months using currently available experimental approaches. We are excited to share with Janssen this foundational technology, which has already proven transformative inhouse.”
About XtalPi
XtalPi is an innovative research platform company powered by artificial intelligence (AI) and robotics. Established in 2015 by three postdoctoral physicists at MIT, XtalPi is dedicated to driving intelligent and digital transformation in the life sciences and materials sciences sectors. XtalPi combines quantum physics, AI, cloud computing, and large-scale robotics to provide R&D solutions, services, and products for pharmaceuticals, biotechnology, renewable energy, and advanced materials industries globally.
About Ailux Biologics
Ailux Biologics is a division of XtalPi dedicated to the innovation in large molecule drug discovery. With a team of around 100 experts, Ailux has established a state-of-the-art biologics discovery lab, a proprietary database purpose-built for AI (AtlaX) and a trio of AI platforms, including a structure modeling suite (XtalFold), a generative large language model for proteins (XenProT) and a predictive AI suite for biologics (Xentient). Ailux partners with pharma and biotech companies to accelerate their biologics programs with AI-powered, lab-validated solutions. To learn more, visit ailuxbio.com and follow us on LinkedIn.
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