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Application

Transforming Biologics Discovery and Engineering

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Enabling applications

Biologics Discovery and Engineering

We harness the power of artificial intelligence, advanced wet lab techniques and expert creativity to transform areas of significant value in biologics discovery and engineering.

Three synergistic AI - Hard targets
Hard targets
  • GPCRs
  • High-homology targets
  • High-selectivity targets
  • Agonist antibody
Three synergistic AI - Next-gen engineering
Next-gen engineering
  • Ultra-fast affinity modulation
  • Species cross-reactivity
  • pH-sensitivity
  • Super humanization
  • Developability optimization
Three synergistic AI - Raise the bar
Raise the bar
  • Greater diversity
  • Improved developability
  • Faster turnaround
Hard Targets

De novo designed GPCR antigen

AI-designed large-scale GPCR mutagenesis to deliver the best antigen for antibody discovery

appl-gpcr-mutagenesis

Enabling rapid antibody discovery in the untapped GPCR target space

Three synergistic AI - Hard targets

GPCR antigen

  • Thermostable
  • Properly folded
  • Well expressed
GPCR antibody

GPCR antibody

  • High-affinity
  • Well functional
  • Developable
Next-Gen Engineering

Ultra-fast AI guided affinity maturation

Rounds of Optimization

Variants Expressed

.5

Weeks

x

Increased in Affinity

Parental 1.53E -7 (M)

Ab-Ag complex structure from primary sequences

In silico

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2025

“Interface” Mutants

25 residues identified at the Ab-Ag interface from XtalFold™ structure

In silico

Generative AI

LLM Trained On Proteins

In silico

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500,000

“Fit” Mutants

Recommended mutants that are developable

In silico

Affinity AI

Rank all mutants by predicted KD

In silico

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Affinity AI

Rank all mutants by predicted KD

In silico

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211

Single-Mutation Combinations

11 single point mutations predicted to increase affinity

In silico

Wet lab data feeds back & optimizes AI model

In silico

23

Expressed & Tested

Cell-free expression & BLI

In vitro

50

Expressed & Tested

CHO expression & BLI/SPR

In vitro

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100x

Top clone 1.53E-9 (M) 5 pt mutations

Amplifying Discovery

Raising the Bar in Biologics Discovery

AI-powered hit selection and amplification from immune repertoire sequencing

Rounds

Expressed

Function Hits

x

Activity Span

Weeks

Raising the Bar in Biologics Discovery

Integrates fully with conventional discovery and engineering

greater-diversity

Greater hit diversity

  • Repertoire NGS
  • Single B cell screening
  • AI-designed display library

 

higher-developability

Improved developability

  • Evaluation and intervention at the earliest stage
  • Multi-parametric assessment powered by AI and wet lab
faster-turnaround

Faster
turnaround

  • Seamless transition between dry lab and web lab
  • Rapid functional validation
  • In vitro and in vivo

Together, let’s push the boundaries of medicine

The future of biotechnology is collaborative. We believe the best solutions come from working together with companies and researchers who share our vision. Are you ready to push the boundaries of what’s possible?

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