We harness the power of artificial intelligence, advanced wet lab techniques and expert creativity to transform areas of significant value in biologics discovery and engineering.
Hard targets
GPCRs
High-homology targets
High-selectivity targets
Agonist antibody
Next-gen engineering
Affinity modulation
Species cross-reactivity
pH sensitivity engineering
Super humanization
Developability optimization
Raise the bar
Greater diversity
Improved developability
Faster turnaround
Hard Targets
De novo designed GPCR antigen
AI-designed large-scale GPCR mutagenesis to deliver the best antigen for antibody discovery
120-160 pt.
mutations in TM & ICL
WT GPCR
Generative AI
160K
Predictive AI
10K
MD Modeling
100
Expression
15
Validation
11
AI-designed Mutants
8 weeks
Enabling rapid antibody discovery in the untapped GPCR target space
GPCR antigen
Thermostable
Properly folded
Well expressed
GPCR antibody
High-affinity
Well functional
Developable
Next-Gen Engineering
AI-powered multi-parameter optimization
Parallel super humanization, developability optimization, and pH sensitivity engineering
Variants Expressed
Weeks
Objectives Achieved Simultaneously
Fold pH Sensitivity
1
Down-select candidate
Ab-Ag complex structure prediction
Identify interface with optimal pH engineering potential
2b
Super humanization & developability optimization
Minimize mouse residues
Enhance developability
2candidates
In silico workflow
In vitro workflow
1 candidate
Virtual histidine scanning
Locate best mutation sites
2a
pH-sensitivity engineering
16 His mut sites
216 Yeast library
15 expressed
28 expressed
1 top variant
1 top variant
1 combined variant
>100-fold pH sensitivity
Ultra-high humanness
Excellent developability
Amplifying Discovery
Raising the Bar in Biologics Discovery
AI-powered hit selection and amplification from immune repertoire sequencing
Rounds
Expressed
Function Hits
x
Activity Span
Weeks
Integrates fully with conventional discovery and engineering
Greater hit diversity
Repertoire NGS
Single B cell screening
AI-designed display library
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Improved developability
Evaluation and intervention at the earliest stage
Multi-parametric assessment powered by AI and wet lab
Faster turnaround
Efficient immune repertoire mining
Accurate binder selection
Comprehensive functional validation
Together, let’s push the boundaries of medicine
The future of biotechnology is collaborative. We believe the best solutions come from working together with companies and researchers who share our vision. Are you ready to push the boundaries of what’s possible?
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