Partner With Us
Application

Transforming Biologics Discovery and Engineering

Down Arrow
Enabling applications

Biologics Discovery and Engineering

We harness the power of artificial intelligence, advanced wet lab techniques and expert creativity to transform areas of significant value in biologics discovery and engineering.

Three synergistic AI - Hard targets
Hard targets
  • GPCRs
  • High-homology targets
  • High-selectivity targets
  • Agonist antibody
Three synergistic AI - Next-gen engineering
Next-gen engineering
  • Affinity modulation
  • Species cross-reactivity
  • pH sensitivity engineering
  • Super humanization
  • Developability optimization
Three synergistic AI - Raise the bar
Raise the bar
  • Greater diversity
  • Improved developability
  • Faster turnaround
Hard Targets

De novo designed GPCR antigen

AI-designed large-scale GPCR mutagenesis to deliver the best antigen for antibody discovery

appl-gpcr-mutagenesis

Enabling rapid antibody discovery in the untapped GPCR target space

Three synergistic AI - Hard targets

GPCR antigen

  • Thermostable
  • Properly folded
  • Well expressed
GPCR antibody

GPCR antibody

  • High-affinity
  • Well functional
  • Developable
Next-Gen Engineering

Ultra-fast AI guided affinity maturation

Rounds of Optimization

Variants Expressed

.5

Weeks

x

Increased in Affinity

Parental 1.53E -7 (M)

Ab-Ag complex structure from primary sequences

In silico

arrow-down

2025

“Interface” Mutants

25 residues identified at the Ab-Ag interface from XtalFold™ structure

In silico

Generative AI

LLM Trained On Proteins

In silico

arrow-right

500,000

“Fit” Mutants

Recommended mutants that are developable

In silico

Affinity AI

Rank all mutants by predicted KD

In silico

angled-right-arrow-down

Affinity AI

Rank all mutants by predicted KD

In silico

angled-left-arrow-down

211

Single-Mutation Combinations

11 single point mutations predicted to increase affinity

In silico

Wet lab data feeds back & optimizes AI model

In silico

23

Expressed & Tested

Cell-free expression & BLI

In vitro

50

Expressed & Tested

CHO expression & BLI/SPR

In vitro

arrow-right

100x

Top clone 1.53E-9 (M) 5 pt mutations

Amplifying Discovery

Raising the Bar in Biologics Discovery

AI-powered hit selection and amplification from immune repertoire sequencing

Rounds

Expressed

Function Hits

x

Activity Span

Weeks

Raising the Bar in Biologics Discovery

Integrates fully with conventional discovery and engineering

greater-diversity

Greater hit diversity

  • Repertoire NGS
  • Single B cell screening
  • AI-designed display library

 

higher-developability

Improved developability

  • Evaluation and intervention at the earliest stage
  • Multi-parametric assessment powered by AI and wet lab
faster-turnaround

Faster
turnaround

  • Efficient immune repertoire mining
  • Accurate binder selection
  • Comprehensive functional validation

Together, let’s push the boundaries of medicine

The future of biotechnology is collaborative. We believe the best solutions come from working together with companies and researchers who share our vision. Are you ready to push the boundaries of what’s possible?

Privacy Settings
We use cookies to enhance your experience while using our website. If you are using our Services via a browser you can restrict, block or remove cookies through your web browser settings. We also use content and scripts from third parties that may use tracking technologies. You can selectively provide your consent below to allow such third party embeds. For complete information about the cookies we use, data we collect and how we process them, please check our Privacy Policy
Youtube
Consent to display content from - Youtube
Vimeo
Consent to display content from - Vimeo
Google Maps
Consent to display content from - Google
Spotify
Consent to display content from - Spotify
Sound Cloud
Consent to display content from - Sound
Partner With Us