We harness the power of artificial intelligence, advanced wet lab techniques and expert creativity to transform areas of significant value in biologics discovery and engineering.
Hard targets
GPCRs
High-homology targets
High-selectivity targets
Agonist antibody
Next-gen engineering
Affinity modulation
Species cross-reactivity
pH sensitivity engineering
Super humanization
Developability optimization
Raise the bar
Greater diversity
Improved developability
Faster turnaround
Hard Targets
De novo designed GPCR antigen
AI-designed large-scale GPCR mutagenesis to deliver the best antigen for antibody discovery
Enabling rapid antibody discovery in the untapped GPCR target space
GPCR antigen
Thermostable
Properly folded
Well expressed
GPCR antibody
High-affinity
Well functional
Developable
Next-Gen Engineering
Ultra-fast AI guided affinity maturation
Rounds of Optimization
Variants Expressed
.5
Weeks
x
Increased in Affinity
Parental 1.53E -7 (M)
Ab-Ag complex structure from primary sequences
In silico
2025
“Interface” Mutants
25 residues identified at the Ab-Ag interface from XtalFold™ structure
In silico
Generative AI
LLM Trained On Proteins
In silico
500,000
“Fit” Mutants
Recommended mutants that are developable
In silico
Affinity AI
Rank all mutants by predicted KD
In silico
Affinity AI
Rank all mutants by predicted KD
In silico
211
Single-Mutation Combinations
11 single point mutations predicted to increase affinity
In silico
Wet lab data feeds back & optimizes AI model
In silico
23
Expressed & Tested
Cell-free expression & BLI
In vitro
50
Expressed & Tested
CHO expression & BLI/SPR
In vitro
100x
Top clone 1.53E-9 (M) 5 pt mutations
Amplifying Discovery
Raising the Bar in Biologics Discovery
AI-powered hit selection and amplification from immune repertoire sequencing
Rounds
Expressed
Function Hits
x
Activity Span
Weeks
Integrates fully with conventional discovery and engineering
Greater hit diversity
Repertoire NGS
Single B cell screening
AI-designed display library
Improved developability
Evaluation and intervention at the earliest stage
Multi-parametric assessment powered by AI and wet lab
Faster turnaround
Efficient immune repertoire mining
Accurate binder selection
Comprehensive functional validation
Together, let’s push the boundaries of medicine
The future of biotechnology is collaborative. We believe the best solutions come from working together with companies and researchers who share our vision. Are you ready to push the boundaries of what’s possible?
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